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tracheal cytotoxin : ウィキペディア英語版 | tracheal cytotoxin
Tracheal cytotoxin (TCT) is a 921 dalton glycopeptide released by ''Bordetella pertussis'' and ''Neisseria gonorrhoeae''. ==History== In 1980, it was discovered that ''B. pertussis'' could attach to hamster tracheal epithelial (HTE) cells, and also, that the supernatant from the cultured bacterium could disrupt the cell cycle of uninfected cells. This prompted the scientists W. E. Goldman, D. G. Klapper, and J. B. Baseman to isolate and characterize a novel substance from ''B. pertussis'' supernatant. The novel disaccharide tetrapeptide that they had purified showed toxicity for HTE cells and tracheal ring cultures. Subsequently, they named the newly sequestered molecule tracheal cytotoxin (TCT).
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